Endocrine Abstracts

Introduction: Dysgonosomies are abnormalities of the number of gonosomes X and Y. They have fewer Phenotypic repercussions than the aneuploidies involving autosomes, and are mostly viable. The 47 XYY are generally boys with normal phenotype. The prevalence is around 1 per 1000 birth boy but undoubtedly under diagnosed given the often normal phenotype associated with this chromosomal formula, in addition to the lack of large-scale studies. There is no gonadal dysgenesis and oft...

Introduction: Dysgonosomies are abnormalities of the number of gonosomes X and Y. They have fewer Phenotypic repercussions than the aneuploidies involving autosomes, and are mostly viable. The 47 XYY are generally boys with normal phenotype. The prevalence is around 1 per 1000 birth boy but undoubtedly under diagnosed given the often normal phenotype associated with this chromosomal formula, in addition to the lack of large-scale studies. There is no gonadal dysgenesis and oft...

Pregnancies in women with acromegaly are rare. Data from the literature report the absence of fetal malformation, a rarely symptomatic increase in adenomatous volume, a possible risk of gestational diabetes and gravidic hypertension in women not controlled before pregnancy. We report the case of a 32-year-old woman, nulliparous, who consults for spaniomenorrhea associated with chronic headaches, in whom the diagnosis of acromegaly was suspected in the face of a very discreet a...

Introduction: Proximal myopathy presents as symmetrical weakness of proximal upper and/or lower limbs. There is a broad range of underlying causes including drugs, alcohol, endocrine and metabolic myopathies such as primary hyperparathyroidism.Observation: We describe a 48-year-old male, hospitalised in neurology departement for exploration of severe proximal myopathy. Cliniquely, he presented progressive debilitating muscle weakness, severe muscle wasti...

Introduction: Prolactin-secreting tumors or prolactinomas comprise the most common pituitary tumor type, acconting of 47-66% of all pituitary tumors. These tumors can be treated with dopaminergic drugs (DA) however 10-15% of prolactinomas are DA resistant.Case 1: A 39 years old man followed for a geant agressif prolactinoma discovered following a progressive decline in visual acuity and associated with visual impairment (diplopia), the MRI of the sellar ...

Introduction: Pituitary adenomas, more recently referred to as pituitary neuroendocrine tumors (PitNets) from other organs, are common neoplasms comprising 10 to 20% on intracranial tumors. Null cell adenoma is a diagnosis of exclusion that requires immunonegativity for all adenohypophyseal hormones and a lack of cell type-specific transcription factors. It represents 0,6% of all pituitary tumors. Case: A 55 years old women with a history of treated thyr...

Introduction: Pituitary adenoma and meningioma are the most benign tumors in the central nervous system (meningioma 35,9%, pituitary tumor: 15,5%). Pituitary adenoma associated with meningioma without a history of radiotherapy is extremely rare.Case: A 70 years old man operated for post-traumatic subdural hematoma in whom the brain MRI (magnetic resonance imaging) had also shown a macroadenoma, completed with an MRI of the sellar region which were confir...